منابع مشابه
Acute megakaryoblastic leukaemia (AMKL) in children: a comparison of AMKL with and without Down syndrome.
To characterize childhood acute megakaryoblastic leukaemia (AMKL), we reviewed 45 children with AMKL diagnosed between 1986 and 2005 at Nagoya University Hospital and Japanese Red Cross Nagoya First Hospital. Twenty-four patients (53%) had AMKL associated with Down syndrome (DS-AMKL) and 21 (47%) had non-DS-AMKL. The median age of the DS-AMKL patients was 21 months (range, 8-38 months) and that...
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The mechanism by which cells decide to skip mitosis to become polyploid is largely undefined. Here we used a high-content image-based screen to identify small-molecule probes that induce polyploidization of megakaryocytic leukemia cells and serve as perturbagens to help understand this process. Our study implicates five networks of kinases that regulate the switch to polyploidy. Moreover, we fi...
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Myocarditis can resemble an acute coronary syndrome (ACS), even an ST-segment elevation myocardial infarction. Furthermore, when a coronary angiogram reveals no significant disease, differential diagnosis can be challenging. Endomyocardial biopsy is still the gold standard for the diagnosis of myocarditis; however, its invasive character and limited sensitivity restrict its generalized applicat...
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We present the case of a patient with pulmonary cavitation of extremely unusual aetiology, which presented a significant diagnostic challenge despite multidisciplinary involvement. A 54-year-old male presented with a 6-week history of haemoptysis associated with fatigue, night sweats and dyspnoea. His past medical history was significant for coronary artery stenting (treated with aspirin). Ther...
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Security is not considered a priority by developers of shrink-wrap systems because without a means to accurately and understandably measure it, security fails to provide a competitive advantage. I assert that the cost to break into a system is an effective metric, that this metric can be measured from the start of testing until product retirement, and that using this metric to differentiate pro...
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ژورنال
عنوان ژورنال: Science-Business eXchange
سال: 2012
ISSN: 1945-3477
DOI: 10.1038/scibx.2012.857